Giorgio Colombo is a Full Professor of Organic Chemistry at the University of Pavia. He holds a PhD in Chemical Sciences. After one year as a visiting scientist in the laboratory of Prof. Ken Merz at the Pennsylvania State University, and a postdoc with profs. H. Berendsen and A. Mark at the University of Groningen, Giorgio Colombo joined the Institute for Molecular Recognition Chemistry, Italian National Research Council, in Milan where he founded the Computational Biochemistry Lab, which he currently heads. In 2017 he moved to the University of Pavia, where he started a new lab of computational chemistry and biology. In January 2021, he has been appointed Coordinator of the PhD School of Chemical and Pharmacological Sciences.
His research aims to explore the links between structure, conformational dynamics and molecular recognition to identify the atomistic determinants of self-organization in biochemical systems, principles of host-guest molecular recognition, and their relationships to the function and the design of new molecules with interesting properties. These objectives are pursued through a combination of existing and newly developed computational and theoretical techniques. Insights gained from these studies are used to define new principles for the design of molecular biosystems with interesting activities. The group has developed simple and efficient methods for the design of allosteric modulators of molecular chaperones, self-organizing systems, diagnostic probes and vaccine candidates from the analysis of the 3D structures of viral (or bacterial) proteins. Research is supported by a number of external national and international grants.